(2014), a systematic review and meta-analysis including 3 randomised controlled trials (RCTs) in 568 children and young people (aged 1 to 17 years) with acute cough caused by an upper respiratory tract infection. No significant difference in sleepiness was found when honey was compared with diphenhydramine (very low quality evidence).īased on Oduwole et al. There were also no significant differences in mild adverse effects (for example, nervousness, insomnia, hyperactivity and drowsiness) compared with dextromethorphan (very low quality evidence). There was no significant difference in gastrointestinal side effects with honey compared with placebo or dextromethorphan (very low to low quality evidence). There was no data on the effect of honey on cough duration because follow-up was for 1 day only. Honey had no significant effect on children's or parents' sleep quality compared with placebo or dextromethorphan, but was significantly better compared with no treatment or diphenhydramine (by about 0.5 to 1 point on a 7-point Likert scale low to moderate quality evidence). Honey significantly reduced bothersome cough by about 2 points on a 7‑point Likert scale compared with placebo (moderate quality evidence), but not compared with no treatment or dextromethorphan (low quality evidence). However, honey did not reduce the frequency and severity of cough at 1 day follow-up compared with an antitussive (dextromethorphan very low quality evidence). Carer responses about cough symptoms ranged from 'extremely' (6 points) to 'not at all' (0 points), but it was not clear how these responses were defined. Honey significantly reduced the frequency and severity of cough at 1 day follow-up compared with placebo, no treatment or an antihistamine (diphenhydramine) by about 0.5 to 2 points on a carer‑reported 7-point Likert scale in children and young people with an acute cough caused by an upper respiratory tract infection (low to moderate quality evidence).
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